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in the episode The Shiny Trinket Maneuver
Penny: Okay, Amy just told you some exciting news, and you acted like it was no big deal.
Sheldon: Oh, I see why you're confused. No, her news sounded important, but what you're forgetting is, it was an achievement in the field of biology. That's all about yucky, squishy things.
This helps us figure out whether you are a human or a cyborg.