Penny: You know, sometimes stuff just happens, and there's nothing you can do about it. For example, Lisa Peterson hasn't talked to me since the 11th grade, because no matter how much you apologize, you can't go back and un-dry-hump someone's boyfriend.
Sheldon: I see. You're saying I'm facing Starfleet Academy's unwinnable command scenario, the Kobayashi Maru.
Penny: Exactly. Sometimes you can't win.
Sheldon: Captain Kirk won.
Penny: Kirk cheated.
Sheldon: Impressive that you know that. It's hard to believe I'm actually having this conversation with you.
Penny: Right there with you.

Sheldon: Woman, you are playing with forces beyond your ken.
Penny: Yeah, well your Ken can kiss my Barbie.

Raj: [to Amy] If you were having Sheldon's baby, would you really want him in the room?
Penny: Yeah, if he's in the room when they're making the baby, I'll give you $10.

Leonard: If I take it off, Sheldon wins.
Penny: Sweetie, every night you don't kill him in his sleep, he wins.

Wolowitz: But you love that spot.
Sheldon: No, I love my mother. My feelings for my spot are much greater.

Penny: OK Sheldon, what can I get ya?
Sheldon: Alcohol.
Penny: Could you be a little more specific?
Sheldon: Ethyl alcohol, 40 millilitres.

Penny: Sheldon, you can't re-program people.
Sheldon: No, you can't re-program people.