Georgie: Look, I mean, I always looked out for him at school. I drove him everywhere. I apologized to people when he was rude.
Leonard: Yeah. I've done all that. I've also removed all the red balloons from his Lucky Charms because they weren't "Irish enough".

Sheldon: This song is never going to stop. Have you ever dealt with something so relentlessly irritating?
Leonard: That's a trick question, right?

Howard: Don't feel bad. Some day someone will be throwing out your work, too.
Leonard: That someone was Sheldon and the day was yesterday.

Sheldon: I remember the song! It's called "Darlin'" by the Beach Boys! Oh, thank goodness! I'm not crazy! I don't have to take a pigeon as my bride!
Leonard: There goes our shot at him living on the roof.

Georgie: After all my sacrifices, guess which kid my mom is the most proud of?
Leonard: If it makes you feel any better, my mom's most proud of Sheldon, too.

Georgie: Picking on him? Is that what he told you?
Leonard: Well, what about the time you threw away his Halloween costume?
Georgie: Well, yeah, 'cause he was gonna dress as some girl scientist.
Leonard: Madame Curie?
Georgie: Oh, I didn't know she was a madam.

Sheldon: Oh, maybe it's fine if she doesn't come to the wedding. I've got Amy now, and she can do everything a mom can do and more.
Leonard: Say that to her on the wedding night. Really spice things up.