Howard: So, my incredible wife has some exciting news.
Bernadette: Howie, stop. I don't want to brag.
Howard: Oh, okay, sorry.
Bernadette: Really? No one's gonna ask?
Leonard: Sorry. What's your news?
Bernadette: The drug I've been working on for the past five years just got approved by the FDA.
Penny: Wow.
Raj: Oh, congratulations. Was that the decongestant you developed?
Bernadette: No, we had to rebrand that as a solvent for mining equipment.

Bernadette: You better find my husband's mother, 'cause one way or another we're walking out of this airport with a dead woman.

Howard: I'm sorry I didn't take you to the airport. I just want you to know I'll never forgive myself for being so selfish. And I promise to keep you close for the rest of my life.
Bernadette: Oh, no, that thing's gonna end up in my bedroom.

Bernadette: Gosh, Amy. I'm sensing a little hostility. Is it maybe because like Sheldon's work, your sex life is also theoretical?

Bernadette: Why don't you want to work with me? I know I can be tough, but that's just 'cause I'm surrounded by useless idiots.

Bernadette: Penny, everybody feels like you do. Like they're not good enough, not smart enough.
Penny: What, even you?
Bernadette: Of course.
Jess: Dr. Rostenkowski, you wanted me-
Bernadette: Hey, did they not teach knocking at Stanford? Get out! (chuckles) I love that kid.

Penny: No, it's not that.
Bernadette: Then why?
Penny: Honestly, I don't know if I'm up to it. You know, the last project I managed was my high school yearbook.
Bernadette: And?
Penny: And that was the year we didn't have one. - And? And that was the year we didn't have one. Apparently, the printers won't make them without getting paid.
Bernadette: What happened to the money?
Penny: Uh, if I didn't know then, I'm not going to magically know now.