Bernadette: So, I talked to your supervisor, and she said that she never stopped you from working on my team, because you never asked her.
Penny: Really? Oh, you know, you should know, she's been taking our new antidepressant, and lying is one of the main side effects.

Leonard: What am I supposed to do?
Penny: Err, keep your mouth off other women.

Penny: At one point, they had me figure out how to get a banana out of a puzzle box.
Leonard: Wait, Sheldon gave me a banana in a box. He was testing me, too.
Penny: Unbelievable.
Leonard: And how could a chimp even solve that? That was impossible.
Penny: Really? You couldn't get it out?

Sheldon: Woman, you are playing with forces beyond your ken.
Penny: Yeah, well your Ken can kiss my Barbie.

Sheldon: Oh, but don't worry. I won't do that to you.
Amy: Maybe you should.
Sheldon: What?
Amy: This has been your lifelong dream. And you may not get another chance. I don't want to be the reason that you don't win a Nobel.
Sheldon: You're the only reason I deserve one.

Bernadette: Look at Howard. He was a disaster when I met him. Now he's a foxy astronaut with a hot wife.
Raj: Wait, he always wanted to be an astronaut.
Bernadette: He thinks that, too. That's how good I am.

Penny: No, it's not that.
Bernadette: Then why?
Penny: Honestly, I don't know if I'm up to it. You know, the last project I managed was my high school yearbook.
Bernadette: And?
Penny: And that was the year we didn't have one. - And? And that was the year we didn't have one. Apparently, the printers won't make them without getting paid.
Bernadette: What happened to the money?
Penny: Uh, if I didn't know then, I'm not going to magically know now.