Howard: My mom's been to Arizona. She rode one of those mules down in the Grand Canyon. Long story short: they had to shoot it.
*Blank look from Bernadette's father*
Howard: ... because she's so fat.
*door rings*
Howard: I'll get the door while you finish laughing.

Howard: You know, I'm really glad you decided to learn Mandarin.
Sheldon: Why?
Howard: Once you're fluent, you'll have a billion more people to annoy instead of me.

Josh: So, I have to ask, was the robot sexy?
Howard: It was actually just a mechanical hand.
Josh: 'Cause that's all you need, right?
Howard: You are my brother.

Sheldon: Sheldon Cooper does not cry.
Howard: That's true, you'd rust.

Penny: Howard, cow tipping - real or not?
Howard: I'm going to say not. That's just based on me trying to roll my mom over when she's snoring.

Amy: It says here you can get an annulment if any of the following conditions were met: Were you unable to consummate the marriage?
Sheldon: Penny!? Ha! Next ...

Mike: I know I'm hard on you, but you're not the worst son-in-law in the world.
Howard: Mike, that's the nicest thing you've ever said to me.
Mike: Well, I'm drunk.