Penny: If you do something cool in science, you might change the world. If I become a famous actress ... I'm not going to tell you why movie stars are the best, they just are.

Sheldon: Woman, you are playing with forces beyond your ken.
Penny: Yeah, well your Ken can kiss my Barbie.

Leonard: What am I supposed to do?
Penny: Err, keep your mouth off other women.

Leonard: If I take it off, Sheldon wins.
Penny: Sweetie, every night you don't kill him in his sleep, he wins.

Leonard: You don't go into science for the money.
Bernadette: Speak for yourself. Last month my company both invented and cured restless eye syndrome. Ka-ching, ya blinky chumps!

Raj: It's too late. He's been murdered by someone in this room. Welcome to another classic Koothrappali murder mystery dinner.
Amy: I'm leaving.

Sheldon: Aren't you gonna come with me?
Howard: While you confront your mother about her sex life? I'd rather go back to that bar in assless chaps.