Bernadette: Hey, Romeo. Repair your relationship on your own time!

Bernadette: Gosh, Amy. I'm sensing a little hostility. Is it maybe because like Sheldon's work, your sex life is also theoretical?

Bernadette: (Shouting from the bathroom) How many times do I have to tell you to replace the toilet paper when it's empty?
Howard: I'm in the middle of something.
Bernadette: So am I!

Leonard: You don't go into science for the money.
Bernadette: Speak for yourself. Last month my company both invented and cured restless eye syndrome. Ka-ching, ya blinky chumps!

Penny: [to Raj] Run to India.

Amy: As my mom used to say, "When you're doing a puzzle, it's like you've got a thousand friends." She was full of fun lies like that.

Bernadette: (Shouting at another driver) Your kid might be a honor student but you're a moron!