Sheldon: Oh, Penny, where do I begin? The simple-mindedness of your idea is exceeded only by its crass consumerism and banality.
Penny: And Leonard didn't want to work with you? Imagine that.

Sheldon: Woman, you are playing with forces beyond your ken.
Penny: Yeah, well your Ken can kiss my Barbie.

Raj: [to Amy] If you were having Sheldon's baby, would you really want him in the room?
Penny: Yeah, if he's in the room when they're making the baby, I'll give you $10.

Leonard: If I take it off, Sheldon wins.
Penny: Sweetie, every night you don't kill him in his sleep, he wins.

Sheldon: I'm not saying that all senior citizens that can't master technology should be publicly flogged. But, if we made an example of one or two it might give the others incentive to try harder.

Raj: Ooh, Leonard is going all alpha nerd on Sheldon's ass.

Leonard: I had a great idea. Do you know how we're always having to stop and solve differential equations, like when you're doing Fourier equations or using the Schroedinger equation?
Sheldon: Howard doesn't, he's only an engineer.