Zack: So, Penny, what's going on with you? How's the job?
Penny: Uh, it's okay, I'm still in pharmaceutical sales.
Leonard: She's doing amazing. She can actually make a side effect, like 10% chance of liver failure, sound like a 90% chance of liver success.

Leonard: What would you be if you were attached to another object by an inclined plane, wrapped helically around an axis?
Sheldon: Screwed?
Leonard: There you go.

Sheldon: This song is never going to stop. Have you ever dealt with something so relentlessly irritating?
Leonard: That's a trick question, right?

Leonard: Penny, as a scientist, my job is to figure out why things happen. But I don't think I'll ever understand how someone like me could get to be with someone like you. You know maybe I don't need to understand it, I just need to be grateful. I love you, Penny.

Sheldon: Physicist, baker, lover, what can't I do?

Penny: I didn't know you could drink while you were breastfeeding.
Bernadette: Yeah, they say the yeast in beer helps with milk production.
Amy: I'm pretty sure that's a myth. Let me check.
Bernadette: Ruin it for me, and I'll break this glass over your head.

Penny: You want food?
Bernadette: Yeah, breastfeeding burns, like, 5,000 calories a day. (To Amy) Do not touch that phone!