Sheldon: So the next time someone on the playground tells you you can only use integral values for the matrix that determines the spin of the anti-proton, you stop being friends with that kid, 'cause he's going nowhere.

Raj: I don't like bugs, okay. They freak me out.
Sheldon: Interesting. You're afraid of insects and women. Ladybugs must render you catatonic.

Sheldon: Scissors cuts paper, paper covers rock, rock crushes lizard, lizard poisons Spock, Spock smashes scissors, scissors decapitates lizard, lizard eats paper, paper disproves Spock, Spock vaporizes rock, and as it always has, rock crushes scissors.

Sheldon: Why are you crying?
Penny: Because I'm stupid.
Sheldon: That's no reason to cry. One cries because one is sad. For example, I cry because others are stupid, and that makes me sad.

Sheldon: Until next week, this is Professor Proton saying, 01000010 01111001 01100101. That's "Bye" in ASCII binary, or good-binary.

Amy: Well, what was wrong with it? You know, did you find it borderline psychotic? I mean, I liked that about it, but you guys discuss.

Sheldon: You can't be Professor Proton. You're not a scientist.
Wil Wheaton: Well, I was never on a starship, but pretending I was bought me this house. And if I'd pretended a little longer, it would have a swimming pool.