Penny: So, you know, isn't there maybe some way you and Sheldon could compromise on this whole presentation thing.
Leonard: No. No. Scientists do not compromise. Our minds are trained to synthesize facts and come to inarguable conclusions. Not to mention, Sheldon is batcrap crazy.

Leonard: What would you be if you were attached to another object by an inclined plane, wrapped helically around an axis?
Sheldon: Screwed?
Leonard: There you go.

Leonard: Penny, as a scientist, my job is to figure out why things happen. But I don't think I'll ever understand how someone like me could get to be with someone like you. You know maybe I don't need to understand it, I just need to be grateful. I love you, Penny.

Sheldon: This song is never going to stop. Have you ever dealt with something so relentlessly irritating?
Leonard: That's a trick question, right?

Leonard: Is this the stuff you want me to try on?
Penny: No this is the stuff I want you to throw out. Seriously, don't even give it to charity. You won't be helping anyone.

Sheldon: Just the latest copy of Applied Particle Physics Quarterly.
Penny: Oh, you know, that is so weird that yours came and mine didn't.

Leonard: You are not Isaac Newton.
Sheldon: No, no, that's true. Gravity would have been apparent to me without the apple.