Leonard: What did your mother say when you told her you were getting married?
Bernadette: He hasn't told her yet. He's waiting for the right time.
Howard: I was thinking of weaving it into her eulogy.

Bernadette: So it's probably genetic.
Howard: Well, maybe. Mom also had just gotten some news that might have upset her.
Bernadette: What?
Howard: It's not important.
Bernadette: Come on, Howard, I'm going to be your wife. You can share anything with me.
Howard: You'd think that. But no.
Bernadette: You told her we were going to get married and she had a heart attack?
Howard: You can't take that personally.
Penny: How else is she supposed to take it?

Sheldon: Howard, I have to go to the bathroom and no one will take me home.
Howard: What's wrong with the bathroom here?
Sheldon: Pneumococcus, streptococcus, staphylococcus and other assorted cocusses.
Howard: Sheldon, my mother is on her deathbed and my fiance is grief-stricken over putting her there. I'm NOT taking you home!
Sheldon: Will you at least go with me to the restroom here so you can open the door and flush the urinal?
Howard: No!
Sheldon: This might be a good time to point out, Howard, that friendship requires a certain give and take.

Priya: Hey, have you and Howard started planning your wedding yet?
Bernadette: Yeah. Were thinking of having it on a cliff overlooking the ocean.
Howard: Nothing soothes those pre-wedding jitters like the thought of falling and drowning.

Bernadette: All right. Here you go. Two lemonades, one iced tea and a root beer for Priya.
Priya: Is it diet?
Bernadette: That's what you ordered.

Howard: So, what do you think? Do you like her? She's great, huh?
Mrs. Wolowitz: She's a lovely girl. Cute as a button.
Howard: That's good to hear, 'cause I've got some news.
Mrs. Wolowitz: I hope it's good news, because I've got nothing but disappointment in here!

Penny: Hey.
Sheldon: Hello.
Penny: Haven't seen you in a while. How's it going?
Sheldon: Oh, other than waiting out the exponential growth period of the virulent organisms trooping through my micro-villi into my circulatory system, hunky-dory. (Penny laughs) Did I say something amusing?
Penny: I don't know. Maybe, I have no idea what you said.

Bernadette: Do you want me to spill hot soup on her?
Penny: Oh, please, you're not that kind of person.
Bernadette: I know. But if she orders something low-fat I'll totally give her the full-fat version.

Howard: Hell hound.
Raj: Who let the satanic dogs out?

Doctor: You brought a Catholic girl home to your mother?
Howard: Yeah.
Doctor: Why don't I write you a prescription for Xanax.

Raj: Sheldon, that's my water.
Sheldon: Oh, dear Lord!
Leonard: That's not your water.
Raj: I know.

Sheldon: So your mirth is merely a discharge of nervous energy with no semantic content at all?
Penny: My mirth. Classic.
Sheldon: Is there a station coming up where I can board your giggling train of thought?
Penny: It's not a big deal, Sheldon. It's just, ever since Leonard's been dating Raj's sister, I've had to keep my distance. I don't get to hear all your jibber-jabber.

Penny: Hey, do me a favor and take table seven.
Bernadette: You mean the one with my one hundred and eighteen-pound rock-hard stud of a fianc who's prone to canker sores and pinkeye?
Penny: Nah, I prefer to look at it as the one with my ex-boyfriend and his gorgeous, successful and sophisticated girlfriend, who makes me feel like a toothless Okie.

Penny: You want to talk about crazy mothers, Leonard's mom wouldn't give him any sort of approval growing up.
Priya: Oh, the poor thing.
Penny: It makes him desperate to please women. That's why the foreplay goes on and on.
Priya: It does, doesn't it?
Penny: It's like he's trying to win a prize. A word of advice, don't doze off. You will never hear the end of it.

Wolowitz: Have you told your parents you're dating this short glass of skim milk?