love big bang
, 14:57 Apr 7 2016.
I think Leslie because Sheldon looks down on her because she is a girl. I think she was the meanest to him although Barry is an asset to the show.
, 06:31 Dec 3 2015.
Leslie always wins over Sheldon and he knows it
Sheldor's worst fan Buzzinga #1 fan
, 00:46 Aug 7 2015.
Wil Wheaton is no longer Sheldon nemesis he is his quote "Friend now and I love your house by the way" ...
, 17:36 Jul 29 2015.
Bawwy is because he gets on Sheldon's nerves the quickest.
, 16:53 Jul 29 2015.
How about his sisiter, Missy!!
Judy Ann Gilliam
, 16:29 Jul 29 2015.
Barry Kripke proved to be smarter than Sheldon.That's that.
, 23:42 Jul 18 2015.
most likely leslie cuz wil and sheldon are friends
Darryl Dean Wright
, 12:54 Mar 29 2014.
I've written the perfect episode for this show but don't know how to get it out, any ideas? It's called; Klingon Altercation...
, 12:25 Mar 29 2014.
definition of Nemesis: a formidable and usually victorious rival or opponent. I would have to say Leslie, with Will right behind her. Both leave Sheldon grasping at straws.
, 16:19 Mar 28 2014.
It's a toss up between Wil and Leslie. But is seems as though Lesiie has been off the show for so long, my vote go's to Wil.