Amy Farrah Fowler: Did you know the iconic heart shape isn't based on an actual human heart, its based on what a woman's rear end looks like bending over
Penny: So in 8th grade, I was dotting my i's with little asses? That's cool.

Sheldon: Woman, you are playing with forces beyond your ken.
Penny: Yeah, well your Ken can kiss my Barbie.

Raj: [to Amy] If you were having Sheldon's baby, would you really want him in the room?
Penny: Yeah, if he's in the room when they're making the baby, I'll give you $10.

Penny: I mean, who even reads Scientific American?
Leonard: It's kind of a big deal.
Penny: If it's such a big deal, how come the biggest celebrity they could get for the cover is a molecule?

Sheldon: You know, in difficult moments like this, I often turn to a force greater than myself.
Amy: Religion?
Sheldon: Star Trek.

Penny: Are you saying that Amy is, oh, what's the scientific word-
Sheldon: Forget science: she's horny.

Amy: Ears and genitalia.
Sheldon: Interesting. Not body parts that usually team up. What about environmental factors. Describe the scene for me?
Amy: I was sitting in a restaurant with Penny and Bernadette drinking water. Carbonated as it was a special occasion. Penny's friend Zack stopped by and said 'hello' and I said 'whoo'.
Sheldon: Who?
Amy: Zack.
Sheldon: Then why did you ask?
Amy: Ask what?
Sheldon: Who?
Amy: Zack.
Sheldon: All right, lets start over. What did you say when Zack walked in?
Amy: 'Whoo'.
Sheldon: Zack.
Amy: Why do you keep saying Zack?
Sheldon: Because you keep saying who?
Amy: I'm not saying 'whoo' now, I said 'whoo' last night.
Sheldon: And the answer is Zack, correct?
Amy: There was no question, I simply said 'whoo'.
Sheldon: All right I think I have enough to go on.