Amy: (Talking about Howard & Raj) They are going to have sex before Sheldon and I do. I knew it!

Amy: Okay, what is going on?
Penny: We just want you to be prepared for any surprises that could happen tomorrow.
Amy: What surprises?
Bernadette: We don't want to spoil anything, but you should know that Sheldon said he's ready to be physical.
Amy: You shut your damn mouth! You actually heard him say this?
Penny: Yes, he said he wants to do something to show you how much you mean to him.
Amy: I can't believe it. I don't know what to say.
Bernadette: Well, we're really happy for you and we know how much-
Amy: I do know what to say. Let's get me waxed!

Sheldon: Sheldon Cooper does not get lucky.
Amy: You and me both, brother.

Amy: Do you have any idea how hard it is to laugh at a knock knock joke that starts "Knock Knock Knock, Amy. Knock Knock Knock, Amy. Knock Knock Knock, Amy"?

Sheldon: Sheldon Cooper does not cry.
Howard: That's true, you'd rust.

Professor Proton: Can I ask you a question?
Leonard: Yeah, sure.
Professor Proton: Why do you put up with Sheldon?
Leonard: Oh, you know because we're friends.
Professor Proton: Why?
Leonard: Wow, you ask really hard questions. Look, I know he can be aggravating, but what you have to remember is he's not doing it on purpose, it's just how he is. But he's also loyal and trustworthy and we have fun together.
Professor Proton: You know you're describing a dog?
Leonard: He did bite me once. But in his defense, I came up behind him while he was eating.
Professor Proton: They hate that.
Leonard: Sheldon is the smartest person I have met. He's a little broken and he needs me. And I guess I need him too.
Professor Proton: Why is that?
Leonard: Boy, you will not let this go, will you?

Sheldon: Arthur! Arthur, it's me, Sheldon Cooper.
Professor Proton: Trust me, I remember.
Sheldon: This is television legend, Arthur Jeffries. His science show inspired millions of children.
Professor Proton: Hold on, you have a girlfriend?
Amy: Yes, and I've heard so much about you. Hey look, we're wearing the orthopaedic shoes. I can't believe I dress like a celebrity.
Professor Proton: Okay, I get it now.