Sheldon: I also have the other kind of will, and in it I will my Wil back to Wil.
Leonard: Will Wil want it?
Wil Wheaton: Wil won't.

Wil Wheaton: Game over, Moonpie.

Wil Wheaton: Did that guy just say "Revenge is a dish best served cold" to me in Klingon?

Wil Wheaton: Hey look, they named their team after me!

Wil Wheaton: Hey, Sheldon. This is Adam Nimoy.
Adam Nimoy: Nice to meet you.
Sheldon: Oh, it's nice to meet you. I admire your father's work very much.
It's not every day I get to meet someone whose life's journey began in my hero's scrotum.

Howard: May I say something?
Bernadette: Is it about how I can't have new wallpaper 'cause your dad left when you were little and your mom died?
Howard: Never mind.

Sheldon: As a child, when faced with a dilemma, my mother encouraged me to ask, "€œWhat would Jesus do?" The answer to that was always, "Love thy neighbor." But my neighbor had a dead tooth, so that wasn't going to happen.
But that's why I changed it to, "€œWhat would Spock do?"
Adam Nimoy: Did you find that helpful?
Sheldon: Yes. Oh, for example, three years ago when I discovered Penny was eating all my Pop-Tarts, instead of getting angry or vindictive, you know, I got a floor safe.
Penny: I knew I could smell 'em.