Sheldon: Oh, no, no, no, of course not. Its just, I was thinking Oh, gosh, golly, I made a boo-boo, and I gave it to Stephen Hawking.
Stephen Hawking: Great, another fainter.

Howard: Sheldon, you're a condescending jerk. Why on earth would I want to do something nice for you?
Sheldon: To go to Jewish heaven.
Howard: Jews don't have heaven.
Sheldon: To avoid Jewish hell?
Howard: Have you met my mother? I live in Jewish hell.

Wolowitz: You don't seem to be understanding the English word no. Maybe a different language will help. Russian: Nyet. Chinese: Bu. Japanese: iie. Klingon: qo. Binary-coded ASCII: 01101110 01101111.
Sheldon: It's actually 01100111.

Mrs. Wolowitz You're right. Who am I kidding? You should have seen me when I was young, Sheldon. The fellas used to line up and bring me boxes of candy. Why did I eat it all? Will you hold me?