Penny: Come on, looks don't matter to Sheldon. ... Because he only has eyes for you!
Amy: Nice try.
Penny: Thanks, I was scrambling.

Sheldon: Woman, you are playing with forces beyond your ken.
Penny: Yeah, well your Ken can kiss my Barbie.

Raj: [to Amy] If you were having Sheldon's baby, would you really want him in the room?
Penny: Yeah, if he's in the room when they're making the baby, I'll give you $10.

Penny: I mean, who even reads Scientific American?
Leonard: It's kind of a big deal.
Penny: If it's such a big deal, how come the biggest celebrity they could get for the cover is a molecule?

Amy: I gave you one job! Keep an eye on him. How hard is that?

Amy: Why didn't you tell me?
Bernadette: We didn't want you to worry.
Amy: Should I worry?
Penny: No, come on, it's Sheldon. Nothing is gonna happen.
Amy: That's what you said to me when I started dating him. And then five years later, bingo-bango, something happened.

Sheldon: Because there's only one of me, I'm more valuable.
Penny: Right.
Sheldon: Although, Amy's already taken me out of my package and played with me.