Penny: I don't see the big deal if my brother comes and stays for a while.
Leonard: If you get him a job, he's gonna live here forever!
Penny: He would get his own place.
Leonard: Has he ever had his own place?
Penny: Yes!
Leonard: Did it have a metal toilet next to the bed?
Penny: It still counts.

Sheldon: Woman, you are playing with forces beyond your ken.
Penny: Yeah, well your Ken can kiss my Barbie.

Raj: [to Amy] If you were having Sheldon's baby, would you really want him in the room?
Penny: Yeah, if he's in the room when they're making the baby, I'll give you $10.

Penny: I mean, who even reads Scientific American?
Leonard: It's kind of a big deal.
Penny: If it's such a big deal, how come the biggest celebrity they could get for the cover is a molecule?

Leonard: He really worked with the Drug Enforcement Agency?
Penny: He didn't know it 'til he was cuffed, but yeah.

Amy: Well, everybody has things that they need help with. Like me. I can't see without my glasses. And right now you're just a cute, pink smudge wearing a childish green smudge.

Bernadette: You know, I just read that a team at MIT developed a device that helps people read human emotions.
Leonard: And you think we can get those guys to reprogram Sheldon? Cool.