Sheldon: Penny, reminder, bowling tonight at seven o'clock.
Penny: Oh, right. Bowling.
Leonard: You don't have to come if you don't want to.
Penny: No, no, it's okay. I mean, let's face it, you guys would get creamed without me.
Sheldon: We would indeed. In this particular case, your lack of femininity works to our advantage.
Penny: It's always nice chatting with you, Sheldon.
Sheldon: Sarcasm?
Penny: Thinly veiled contempt.

Sheldon: Woman, you are playing with forces beyond your ken.
Penny: Yeah, well your Ken can kiss my Barbie.

Raj: [to Amy] If you were having Sheldon's baby, would you really want him in the room?
Penny: Yeah, if he's in the room when they're making the baby, I'll give you $10.

Penny: I mean, who even reads Scientific American?
Leonard: It's kind of a big deal.
Penny: If it's such a big deal, how come the biggest celebrity they could get for the cover is a molecule?

Sheldon: You did this, didn't you?
Wil Wheaton: Come on, Sheldon, do you really think I'd break up a couple just to win a bowling game?
Sheldon: No, I suppose not.
Wil Wheaton: Good. Keep thinking that.
Sheldon: Wheeeeatoooon!

Sheldon: Well, well, well, if it isn't Wil Wheaton. The Green Goblin to my Spider-Man, the Pope Paul V to my Galileo, the Internet Explorer to my Firefox!

Sheldon: I am the ball, my thoughts are its thoughts, its holes are my holes.