Penny: I don't care about Alex. Fine, I care. Okay, I hate that bitch. But what really hurt is that you liked it so much. I mean, do I need to be worried?
Leonard: Of course not. No. Why?
Penny: Because, she is pretty and smart, and when you talk about work, she doesn't have to go home and look up words in the dictionary to understand what you said.

Leonard: If I take it off, Sheldon wins.
Penny: Sweetie, every night you don't kill him in his sleep, he wins.

Penny: I mean, who even reads Scientific American?
Leonard: It's kind of a big deal.
Penny: If it's such a big deal, how come the biggest celebrity they could get for the cover is a molecule?

Howard: I'm not signing a prenup.
Penny: All right, Howard Wolowitz, listen up! You sign anything she puts in front of you, because you are the luckiest man alive. If you let her go, there is no way you can find anyone else. Speaking on behalf of all women, it is not going to happen, we had a meeting.

Amy: I have a lab full of coked up monkeys with nothing to lose.

Raj: I did the research. Tony the Tiger, Dig'em the Frog, Cap'n Crunch, Toucan Sam, Count Chocula, Trix the Rabbit, Snap, Crackle and Pop. Not one cereal mascot is a girl. It's a total breakfast sausage fest.
Leonard: Are we done with this?
Raj: Almost. Franken Berry, Boo Berry, Sugar Bear and the Honey Nut Cheerio bee, I believe his name is Buzz.

Sheldon: My father used to say that a woman is like an egg salad sandwich on a warm Texas day.
Alex: What?
Sheldon: Full of eggs and only appealing for a short time.