Sheldon: Well, regardless, she has a distinct advantage in all tavern-based competitions. Pool, beer pong, wet T-shirt contests, they're all out.
Penny: Okay. Just for the record, I have never entered a wet T-shirt contest. I've won a few, but that's just because I spill when I'm drunk, so...

Leonard: If I take it off, Sheldon wins.
Penny: Sweetie, every night you don't kill him in his sleep, he wins.

Penny: I mean, who even reads Scientific American?
Leonard: It's kind of a big deal.
Penny: If it's such a big deal, how come the biggest celebrity they could get for the cover is a molecule?

Sheldon: Woman, you are playing with forces beyond your ken.
Penny: Yeah, well your Ken can kiss my Barbie.

Howard: Wow, so you guys are like buds now?
Raj: Oh, yeah, we hang out all the time.
Stuart: Plus, he doesn't have a girlfriend, I don't have a girlfriend.
Raj: It's like we both had these holes in our lives, but now we fill each other's holes.
Stuart: That sounds a little funny to an American ear.
Raj: Which part?
Stuart: Just all of it.

Amy: We could go to the cadaver lab at UCLA and play real-life Operation.
Leonard: Uh-uh.
Sheldon: No.
Penny: I don't think so.
Amy: Are you sure? I mean, the nose doesn't light up, but if the corpse is fresh enough, sometimes you can get the leg to jerk.

Penny: You're unbelievable.
Sheldon: I know.