For years, fans have been delighted watching their favorite physicists Leonard (Johnny Galecki) and Sheldon (Jim Parsons) navigate the universe and everyday life along with Penny (Kaley Cuoco), and fellow scientists Howard (Simon Helberg), Raj (Kunal Nayyar), Amy (Mayim Bialik) and Bernadette (Melissa Rauch), as well as other beloved characters. Now that Sheldon has married neurobiologist Amy Farrah Fowler, he'll have to make some serious adjustments to their "Relationship Agreement" in Season 12. Will their equation for marital bliss alter the chemistry between these two beautiful minds? Perhaps Leonard and Penny will provide the data as they experiment with variable in their own marriage. Meanwhile, Howard and Bernadette explore the principles of parenthood, and Raj considers a traditional arranged marriage. Quantum comedy converges in the twelfth dimension for the final season!