Sheldon: I brought you two hot dogs.
Amy: Aren't you gonna eat one?
Sheldon: From a street cart? Are you crazy? I'm amazed that I'm holding them.

Sheldon: You realize that I'm not a particularly physical person.
Amy: I know.
Sheldon: When I was little, and people asked me what I wanted to be when I grew up, I'd always say, "A brain in a jar."
Amy: Sure.

Sheldon: I'm just worried that if I don't schedule our bedroom endeavors, then I may not think about them, and you'll grow cold and distant and seek solace in the arms of a heavily-muscled longshoreman.
Amy: Where would I find a longshoreman?
Sheldon: Along the shore. It's in the name.

Amy: Sheldon, I could never be with anybody but you.
Sheldon: That's good to know. I wouldn't want to fight a man who's brave enough to touch a fish.

Sheldon: Look, it doesn't have to just be New York. That's the beauty of it. Uh, the initials "N.Y." can stand for anything you like. For instance, I understand that there is an elderly rock-and-roll musician named Neil Young. Perhaps you heart him. Or if not him, Egyptian table tennis silver medalist Noha Yossry. Or Nana Yamaguchi, the Japanese voice actress who starred in Sally the Witch.
Raj: Did you just Google the initials "N.Y."?
Sheldon: I had Wi-Fi and a long plane flight. Draw your own conclusions.

Amy: Well, Leonard and Penny are our best friends. They know us better than anyone. They said it's the perfect gift. We must be missing something. You don't think it's a marital aid, do you?
Sheldon: Don't be silly. Amy, how is this big glass shaft going to aid our marriage?

Amy: Let's just go to sleep. We'll look at it in the morning with fresh eyes, and maybe it'll come to us.
Sheldon: Fine.
Amy: Or we go tear apart that box and look for a clue.
Sheldon: Staying up past my bedtime and solving mysteries? Who knew married life could be this good?

Amy: You're really letting your father pick out a wife?
Raj: Why not? Arranged marriages have been working for thousands of years. Anu and I come from similar backgrounds, our families get along and we each filled out questionnaires, so we know we're not wasting our time with someone who's not compatible.
Penny: Oh, that sounds so dry and clinical.
Sheldon: You lucky duck.

Sheldon: Well, I, for one, applaud Raj's decision to forgo emotional attachment and find a life partner by bowing to a 3,000-year-old authoritarian tradition.
Leonard: What are you talking about? You married a woman you're in love with.
Sheldon: I can't believe you're throwing that back in my face.

Sheldon: You're awfully quiet.
Leonard: Sorry.
Sheldon: No, I like it.
Leonard: Got a lot on my mind.
Sheldon: Would you like to talk about it?
Leonard: Not really.
Sheldon: Grape Nuts for breakfast, quiet car ride, things are really breaking my way today.

Sheldon: When I moved to California, what did you do?
Tam: I stayed in Texas.
Sheldon: Do you believe this guy?!

Sheldon: Howard, today is your lucky day. Leonard's out, you're my new best friend. Well, I'm not thrilled about it either, but here we are. Okay, fine. Is Bernadette there? Sh- No? Just Stuart? Let me call you back.

Tam: Sheldon, come here.
Sheldon: Bazinga!

[After montage of classic The Big Bang Theory moments with Tam as Sheldon's roommate]
Sheldon: No, my life would've still been great.

Tam: I didn't mean to upset you. And I want you to know I'm really proud of everything you've done.
Sheldon: Thank you. It did work out for me. And I'm sorry that things didn't work out for you.
Tam: They did work out for me.
Sheldon: Oh, Tam, you don't need to be brave on my account.
Tam: I'm not. I have a great wife and amazing children. I'm very happy.
Sheldon: Brave, brave Tam.