Sheldon: Oh gravity, thou art a heartless bitch.

Sheldon: I have a masters and two PhDs. I should not have to do this.

Penny: Yes, I know men can't fly.
Sheldon: No, no let's assume that they can. Lois Lane is falling, accelerating at an initial rate of 32ft per second, per second. Superman swoops down to save her by reaching out two arms of steel. Ms. Lane, who is now traveling at approximately 120 miles per hour, hits them, and is immediately sliced into three equal pieces.
Leonard: Unless Superman matches her speed and decelerates.
Sheldon: In what space, sir, in what space? She's two feet above the ground. Frankly, if he really loved her, he'd let her hit the pavement. It would be a more merciful death.

Howard: Grab a napkin, homey, you just got served.
Leonard: That's fine, you win.
Howard: What's his problem?
Sheldon: His imaginary girlfriend broke up with him.
Howard: Been there!

Penny: And what kind of doctor removes shoes from asses?

Leonard: Do you have any ideas?
Sheldon: Yes, but they all involve a Green Lantern and a Power Ring.

Leonard: Sheldon, this is not your home!
Sheldon: This isn't anyone's 'home'. This is a swirling vortex of entropy.

Sheldon: I couldn't sleep knowing that just outside my bedroom is our living room and just outside our living room is that hallway and immediately adjacent to that hallway is this!
Leonard: Do you realize if Penny wakes up there's no reasonable explanation to why we are here?
Sheldon: I just gave you a reasonable explanation.
Leonard: No, no. You gave me an explanation. Its reasonableness will be determined by a jury of your peers.
Sheldon: Don't be silly. I have no peers.

Sheldon: If you have time to lean you have time to clean.

Leonard: You convinced me. Maybe tonight we should sneak in and shampoo her carpet?
Sheldon: You don't think that crosses a line?
Leonard: Yes! For God's sake, Sheldon, do I have to hold up a sarcasm sign every time I open my mouth?
Sheldon: You have a sarcasm sign?

Leonard: I guess we'll just take [a TV cabinet] up [the stairs] ourselves.
Sheldon: We don't have a dolly, or lifting belts, or any measurable upper-body strength.
Leonard: We don't need strength. We're physicists. We are the intellectual descendants of Archimedes. Give me a fulcrum and a lever, and I can move the Earth. (Trying to move the box) It's just a matter of... I don't have this. I don't have this. I don't have it!
Sheldon: Archimedes would be so proud.

Leonard: You're going march yourself over there right now and apologize.
Sheldon: Pfffft.
Leonard: What's funny?
Sheldon: That wasn't sarcasm?
Leonard: No!
Sheldon: Oh. Boy, you are all over the place this morning.

Sheldon: Great Caesar's Ghost, look at this place!
Leonard: So Penny's a little messy.
Sheldon: A little messy? The Mandelbrot set of complex numbers is a little messy, this is chaos.

Sheldon: I have to say, I slept splendidly. Granted, not long, but just deeply and well.
Leonard: I'm not surprised. A well known folk cure for insomnia is to break into your neighbor's apartment and clean.
Sheldon: Sarcasm?
Leonard: You think?

Penny: Son of a bitch!
Leonard: Penny's up
Penny: You sick, geeky bastards!
Leonard: How did she know it was us?
Sheldon: I may have left a suggested organizational schematic for her bedroom closet.
Penny: Leonard!
Leonard: God this is going to be bad.
Sheldon: Good bye, Honey Puffs. Hello, Big Bran.