Sheldon: I'm not saying that all senior citizens that can't master technology should be publicly flogged. But, if we made an example of one or two it might give the others incentive to try harder.

Raj: Ooh, Leonard is going all alpha nerd on Sheldon's ass.

Leonard: I had a great idea. Do you know how we're always having to stop and solve differential equations, like when you're doing Fourier equations or using the Schroedinger equation?
Sheldon: Howard doesn't, he's only an engineer.

Raj: Last night I had a dream we got so rich from the app, you and I bought matching side by side mansions, but there was a secret tunnel connecting your front yard to my back yard. What do you think that means?

Sheldon: Hear me out. The atomic bomb was the Manhattan project, Windows 95 was Project Chicago, for our app I humbly suggest Project Nodlehs.

Leonard: Look, I'm still happy to drive you to work. Nothing's changed in that regard. We're still roommates. We're still friends.
Sheldon: Except you identified me, your best friend, as a gangrenous limb that needed to be severed from the organism and tossed away. The desperate act of a little man with a big Napoleon complex.
Leonard: You know what? Go put on your bus pants.

Leonard: What are you doing?
Sheldon: Playing the theremin.
Leonard: No. I mean, what are you doing with a theremin?
Sheldon: Playing it.

Sheldon: I've loved the theremin from the first moment I heard the original Star Trek theme. And it's been killing me that it just sits in my closet, gathering dust.
Leonard: Sheldon, we're working here!
Sheldon: That's all right. I can barely hear you over my theremin. (Leonard pulls the plug) Well, that was a little uncalled for.
Leonard: No, that was completely called for. We need quiet.
Sheldon: So, your project is more important than mine?
Leonard: Well, seeing as your project is to sabotage my project, yes.
Sheldon: Dont beat around the bush, Leonard. If you dont want me here, just say the word, and Ill leave.
(cut to Sheldon in the hallway outside the apartment)
Sheldon: Could have beaten around the bush a little.

Sheldon: # Nobody knows the trouble I've seen. Nobody knows my sorrow. #

Leonard: So this button here will allow you to scan a new equation, but over here, you can press this and just substitute new values for the coefficients.
Sheldon: Good one, boss.
Leonard: What?
Sheldon: This diagram. I assume you were opening with a joke. It certainly buoyed up this employee's esprit de corps.
Leonard: It's not a joke. It's the real design.
Sheldon: In that case, may I offer 27 little tweaks to make it slightly less embarrassing?

Howard: A few extra bucks would be nice. I could finally move out of my mother's house.
Raj: Where would you go?
Howard: I always dreamed about building a little place of my own over the garage.

Sheldon: She befriends them and then lies in wait until they reveal a marketable idea, which she steals and sells to the highest bidder.
Leonard: That's ridiculous.
Sheldon: Oh, is it? Well, let's see you come up with an explanation as to why this woman hangs out with us all the time.
Penny: Oh, great. You know what? I've already mooched dinner off you guys. I don't need to listen to this.
Howard: There's your answer: free food.

Raj: Hey, why am I in charge of phone support? Seems a bit racist.
Sheldon: A customer service representative with an Indian accent will create the impression that we're a vast enterprise that uses overseas call centers.
Raj: Oh, very clever. But still racist.
Sheldon: Duly noted, Steve from Wichita.

Howard: Why am I listed as your executive assistant?
Sheldon: Because the word secretary has fallen into disrepute. FYI, my mother's birthday is coming up. I'm going to need you to pick up a present.

Sheldon: Look at the organizational chart. You're clearly listed as founder.
Leonard: Well, yes, and you're listed as Chief Executive Officer, Chief Financial Officer and Chief Operating Officer.
Sheldon: You missed Chief Science Officer, Chairman of the Board, and Head of the Secret Santa Committee.