Bernadette: Boy, I don't know if I could be friends with Howie if we broke up.
Howard: Why not?
Bernadette: I'm a very vengeful person.
Howard: Really?
Bernadette: With access to weaponized smallpox.

Sheldon: Does anybody have any wood? Oh, come on! I just want wood. Why are you making it so hard?

Sheldon: I know he (Spock) wouldn't care for an outburst of human emotion, but oh goodie, oh goodie, oh goodie!

Sheldon: And now that I have some wood, I'm going to begin the erection of my settlement.

Leonard: Penny, do you have plans for dinner?
Penny: Why, you guys going somewhere?
Leonard: No, just you and me.
Penny: Have you thought this through?
Leonard: Yes, and I think we should go anyway.

Sheldon: Oh no, they sent the wrong Spock. Live long and suck it, Zachary Quinto!

Leonard: Some kind of nerd? I'm the king of nerds.
Penny: What does that mean?
Leonard: It means that if someone makes me mad, I won't help them set up their printer.

Leonard: You feel like trying something new for dinner? Maybe Indian, Tex-Mex?
Sheldon: You ever wonder how humans would be different if they evolved from lizards instead of mammals?
Leonard: Okay, let's talk about that.
Sheldon: As you know, lizards, cold-blooded animals, lack the ability to sense temperature. But they do move more sluggishly when it's cold. So, lizard weathermen would say things like, bring a sweater, it's slow outside. I love my mind.
Leonard: We all do. Now, how about dinner?
Sheldon: Oh, I would assume we'd enjoy insects or smaller lizards. We could also pull each other's tails off and grill them, they'll just grow back.

Leonard: What are you afraid of?
Penny: Well, what if we do go out and I do something stupid and dump you again.
Leonard: What if I dump you?
Penny: [Scoffs] Come on, be serious.

Leonard: How does a miserable date end in sex?
Penny: I don't know, it's complicated.
Leonard: Well, I'm a pretty smart guy and right now my brain has dibs on the blood supply so give it a go.

Raj: Did you forget what Penny did to you? It took two years and defiling my sister to turn that frown upside down.
Leonard: I didn't defile your sister, we had a relationship.
Raj: I heard you called her Brown Sugar. In my book, that's defilement.

Sheldon: Now, back to our game.
Raj: You were in the middle of an erection.
Sheldon: Oh, of course. It's right here in my hand.

Sheldon: Why would I feel safer with Zachary Quinto at the foot of my bed?
Leonard: I don't know, he was pretty bad ass on Heroes.
Sheldon: Nope. Sorry Quinto, you're going back!

Penny: You mean, like a date?
Leonard: Not like a date, a date.

Leonard: Penny and Leonard 2.0. We can test it internally, shake out the bugs, and if we both think it is solid, we roll it out to the public.

Leonard: Obviously, when I saw that you were in ours, I went and used another one.
Sheldon: Where?
Leonard: The gas station across the street.
Sheldon: In your pajamas?
Leonard: Yes.
Sheldon: Without shoes?
Leonard: Yes.
Sheldon: On a cold winter's night?
Leonard: Yes.
Sheldon: Seems unlikely. Did you bring your asthma inhaler?
Leonard: Uh, uh, uh. Yes, I did!
Sheldon: Well, then, I guess it's plausible.

Sheldon: Leonard?
Leonard: Yeah, hi, hi. How's it going?
Sheldon: Uh, can't complain. Thanks for asking. What were you doing out at three o'clock in the morning?
Leonard: Well, uh - uh, what are you doing up?
Sheldon: I was using the bathroom.
Leonard: Yeah, well, so was I.
Sheldon: Really? I didn't see you in there.

Amy: If you and Leonard get back together, Sheldon and I will finally have someone to go on double dates with.
Bernadette: What about me and Howard?
Amy: Fine, we can double with you, too. So insecure.

Sheldon: Leonard, promise me that when our new waitress comes over, you will not start a complicated on-again, off-again relationship with her, because I am very, very hungry.

Penny: You know why we can't be together? Because you always have to be right.
Leonard: Oh, that is not true.
Sheldon: I've got to go with Leonard on this. He is wrong more than anyone I know.

Sheldon: People, people, please, before you say something you both regret, I'd like to place my order.

Penny: No, that's okay, Bernadette. Sometimes these things just don't work out.
Leonard: Yeah, it's all good. We'll always have feelings for each other.
Bernadette: Oh, that's nice.
Leonard: See, she knew what always meant.

Leonard: We are next to a Subaru with a Gore/Lieberman bumper sticker.
Sheldon: Well, I doubt they'd want to talk about that, so we're fine.

Bernadette: I'm so disappointed it didn't work with him and Penny.
Amy: Me, too. Out of deference to them, let's not flaunt our happy relationship.
Sheldon: You have a keen insight into the human heart, Amy Farrah Fowler.

Sheldon: Leonard will be here in a moment. He's looking for a different parking space.
Howard: Why?
Sheldon: We were next to a car with an ask me about my grandchildren bumper sticker, and I was afraid if we ran into them on the way out, I'd be obligated to do so.

Sheldon: Hang on a second, mister.
Leonard: What?
Sheldon: After you used the facilities at the gas station, did you make a purchase?
Leonard: What?
Sheldon: It's customary when using the rest room at a retail establishment to make a small purchase. Did you?
Leonard: No.
Sheldon: Here's two dollars. Go buy some beef jerky.
Leonard: I don't want beef jerky.
Sheldon: It's not about you. It's about a poor immigrant from Pakistan trying to make his way in America by working the graveyard shift at the Colorado Boulevard Chevron.
Leonard: Fine.
Sheldon: Needy Baby, Greedy Baby indeed.

Penny: Hey, I just remembered. I still got one of your inhalers.
Leonard: I can't believe you kept this.
Penny: Yeah, I was gonna throw it away, but I just couldn't.
Leonard: That is so sweet. In 25 to 30 minutes I'm gonna show you how much this means to me.

Penny: Well, that was fun.
Leonard: Yeah, except for when I got the foot cramp.
Penny: You hung in there, though.
Leonard: Well, there was a lot at stake.

Penny: See, this is where everything goes wrong, when we talk.
Leonard: Well, I don't know how you have a relationship without talking.
Penny: Hey, I went out with this guy TJ for eight months. We never talked. To this day, I don't even know what TJ stands for.
Leonard: Wait, if you guys didn't talk, what did you ... Never mind, stupid question.

Penny: You're over-thinking this.
Leonard: No, I'm not.
Penny: Yes, you are. You always over-think things.
Leonard: Ah, now there you go. Always made it worse.

Leonard: You said always. You'll always have feelings for me.
Penny: So?
Leonard: So, that sounds more like something you'd say if you didn't want a relationship with someone. This isn't working out, but I'll always have feelings for you. I'm sorry I slept with your best friend, but I'll always have feelings for you. Here's the thing, Lisa, I'm into dudes now, but I'll always have feelings for you.

Penny: You are so funny.
Leonard: Good. Remember that when I take my shirt off.

Leonard: Uh, let's see. Uh, I am an experimental physicist at Cal-Tech, most of my research is with high-powered lasers, and, oh, I've just gotten a big government grant to see if they can be used to knock out incoming ballistic missiles.
Penny: Wow. Can they?
Leonard: Oh, God, no. The money's pretty good. And I used the equipment to make my own Bat-signal.

Penny: Okay, uh, let's see. I'm from Nebraska, and ever since I was a little girl, I dreamed of moving to L.A. and becoming a movie star. Anyway, after four years of acting lessons and waiting tables, I've done a hemorrhoid commercial and a production of Anne Frank above a bowling alley. So, you know, dreams do come true.

Leonard: Hey, how about if we pretend we're actually on a first date? See how that goes.
Penny: Okay.
Leonard: So, Polly, tell me about yourself.
Penny: It's Penny.
Leonard: Oh, sorry, yeah. Awkward.

Leonard: So, do they have a name for a first date with someone you used to go out with?
Penny: Oh, that's a good question. How about awkward?
Leonard: Yeah, that sounds right.

Raj: If they ever make a movie version of that book, you know who should play Leonard's mother? Sandra Bullock.
Howard: Why?
Raj: Because she's great in everything.

Sheldon: The reason you're fixated on a good-natured simpleton like Penny is that she's the exact opposite of your first romantic attachment, your brilliant yet intimidating mother.
Leonard: Where on earth did you get that from?
Sheldon: It's in her book, "Needy Baby, Greedy Baby".
Leonard: That doesn't make it true.
Sheldon: It's called non-fiction for a reason, Leonard.

Sheldon: I don't understand the laughter. The object of Settlers of Catan is to build roads and settlements. To do so requires wood. Now, I have sheep. I need wood. Who has wood for my sheep?

Bernadette: Relax, you know Leonard's always been crazy about you. It's gonna be great.
Penny: I know, but we've finally gotten to a place where we can hang out without it being weird. And what if something goes wrong? Then what?
Amy: Guess it'll just be Sheldon and me going on a double date with Howard and Bernadette.
Bernadette: Sure, we'd love that. (To Penny) Change your clothes, we got a lot riding on this.

Bernadette: You can make-believe, though. Sometimes Howard and I pretend that his arrhythmia is acting up and I'm a sexy cardiologist. And the naughty part is I'm not in his HMO network.

Bernadette: Do you think you'll sleep with him tonight?
Penny: Absolutely not. Look, we're just gonna have dinner and, you know, see how it goes.
Amy: If he were dying, would you sleep with him?
Penny: What?
Amy: Assuming he were dying of something that couldn't be sexually transmitted. You know, like a spear wound to the head.
Penny: Okay, he is not dying.
Amy: How do you know? Are you a doctor?

Bernadette: Why do you think he asked you out again?
Penny: I don't know.
Amy: Maybe he's dying. That would be so romantic.
Penny: He's not dying.
Amy: Too bad. If he were, she could just throw him in bed and ride him right up until he flatlines.