Howard: I'm not signing a prenup.
Penny: All right, Howard Wolowitz, listen up! You sign anything she puts in front of you, because you are the luckiest man alive. If you let her go, there is no way you can find anyone else. Speaking on behalf of all women, it is not going to happen, we had a meeting.

Penny: So you're saying if I became a famous movie star, we got married, you wouldn't sign a pre-nup?
Leonard: Absolutely not! If I'm gonna be stuck at home with the kids while you're on location cheating on me with Ryan Gosling, then Leonard gots to get paid.

Penny: Hey, what are you guys doing here?
Howard: We're grown men, we drink at bars.
Penny: No and no. Everything okay with you and Bernadette?
Howard: Oh yeah, sure.
Penny: You and Amy? Good?
Sheldon: Oh, better than good.
Penny: You know those girls text me every detail of their lives as it happens.

Sheldon: Gentlemen, I think I've come up with a fun way to get young people interested in science. Physics Mad-Libs. Now, give me a number.
Leonard: Five.
Sheldon: Uh-huh. And an irrational constant.
Howard: E.
Sheldon: And a funny Greek letter.
Raj: Gamma.
Sheldon: I said funny.
Raj: Upsilon?
Sheldon: Good one. And an electrical charge.
Leonard: Positive.
Sheldon: Ha. Perfect. Okay. Get this. Professor Jones told the symposium he had a new method for calculating the mass of a muon. Five times the limit of E to the upsilon as in a ... (laughs uncontrollably) ... Okay. No, no. I'll start over. Professor ... (laughs again).

Bernadette: Oh, I don't know. I don't want to manipulate him with sex.
Penny: Oh, sweetie, that's what sex is for.

Sheldon: Boy, oh, boy. This vacation is off to a wonderful start. The smell of formaldehyde, the whir of the centrifuge, the distant chatter of lab animals being dispatched for dissection. Mm, I can already feel my cares just melting away.
Amy: I'm excited to work with my boyfriend. It's going to be romantic.
Sheldon: Way to kill the mood.

Amy: Oh, are we nervous, Dr. Cooper?
Sheldon: No. What you see is a man trembling with confidence.

Bernadette: And just to be safe, when you talk to him don't bring up Jimmy Carter, gardeners, foreign people, homosexuals, Sean Penn, Vatican II, gun control, organic food, the designated hitter rule, recycling or the fact that you're Jewish.

Sheldon: This is now the only lab with glassware washed by a man with two doctorates and a restraining order signed by Carl Sagan.
Amy: Soap spots. Wash them again.

Howard: Why don't I talk to him about it in May?
Bernadette: In May, you're gonna be on the International Space Station.
Howard: They got a phone.

Sheldon: Biologists are mean.

Sheldon: You've got the brilliant Sheldon Cooper in your lab and are going to ask him to do the dishes? That's like asking the Incredible Hulk to open a pickle jar.

Sheldon: Hawaii is a former leper colony on top of an active Volcano where the disappointing ending to Lost was filmed. Mahalo for nothing, Hawaii.

Amy: Sheldon, you've never worked in a lab like this before. You have no experience in the field of biology.
Sheldon: I have plenty of experience in biology. I bought a Tamagotchi in 1998. And it's still alive. Let's do this.

Penny: You know I'm a big believer in breaking bad news to a guy when you're in bed with him. That's how I told my high school boyfriend I slept with his brother. That's how I told his brother the same thing.