Sheldon: As hard as this is I have to move on. I can't keep postulating multi-dimensional entities and get nothing in return. I have needs too!

Sheldon: Why do we have a geology book? Leonard, did you throw a children's party while I was in Texas?

Penny: How about we toast your new found freedom?
Sheldon: Normally I refrain from alcohol, but since my cerebral cortex is twiddling its proverbial thumbs. Why not soak it in grape juice that's been predigested by a fungus?
Penny: And you wonder why other children beat you with books. Cheers!

Sheldon: Well, I've had a lot on my plate. We happen to live in a golden age of television.

Raj: Being an astrophysicist right now is like being a rock star.
Howard: Only without the sex.
Raj: Yeah, literally none of it.

Sheldon: I suppose I could see myself in a scientific boyband. Of course I'd be the dreamy one and the smart one.

Sheldon: Why would you do that? You're a string theorist as well.
Barry Kripke: Incorrect. I'm a string pragmatist. I say I'm going to prove something that can not be proved. I apply for grant money and then I spend it on liquor and broads.

Barry Kripke: Excuse me, fellas. Sorry for eavesdropping, but there actually was some big string theory news out of the Hadron Collider.
Sheldon: Really? Did they find evidence to support extra dimensions or super-symmetry?
Barry Kripke: No, but they did find evidence you'll believe anything

Penny: I get it. I know what it's like to put your heart and soul into something and get nothing out of it.
Sheldon: You mean your acting career?
Penny: No.
Sheldon: Your relationship with Leonard?
Penny: No.
Sheldon: Your failed attempt to go back to college?
Penny: No!

Sheldon: Do you think he's right? Am I wasting my life on a theory that can't be proved?
Howard: Maybe. But how great is Game of Thrones?

Bernadette: How's your soup?
Howard: It's all right. They could have filled the bowl a little more.
*Raj and Emily start laughing*

Emily: It's fine. All my friends love this story. They call you Clogzilla.
Raj: Get it? Because you clogged up her bathroom like a radioactive monster.

Bernadette: Where are you going?
Howard: I need some fresh air.
Emily: Been there!

Howard: Hey, it's not like cotton candy comes out of you.