Georgie: You have no idea what you are talking about.
Leonard: Ooh, there. That, that was very Sheldon.

Leonard: What would you be if you were attached to another object by an inclined plane, wrapped helically around an axis?
Sheldon: Screwed?
Leonard: There you go.

Leonard: My point is, while you're spending all this time on your own, building computers or practicing your cello, what you're really doing is becoming interesting. When people finally do notice you, they're gonna find someone a lot cooler than they thought. And for those of you that were popular in high school, it's over, sorry. Thank you. Congratulations.

Leonard: [to a "smiling" Sheldon] We're here to see Koothrappali, not kill Batman.

Georgie: You went away to college after Dad died. Who do you think took care of everything?
Sheldon: Mom did. Mom always took care of everything.
Georgie: Mom was a mess, Missy was a dumb teenager. I had to look after both of 'em.
Sheldon: I talked to Mom all the time. If she was upset, she would have told me.
Georgie: She was protecting you, you idiot, just like everyone always does.
Sheldon: If things were bad, then why didn't you tell me?
Georgie: Because I was protecting you, too. (sighs) You're my baby brother, Sheldon. I know life has been hard for you, but that don't mean it's been easy for the rest of us.

Sheldon: I would like you at my wedding.
Georgie: Thank you, Sheldon. That is so nice to hear. But I would rather swallow a pregnant wildcat and crap out a litter of kittens.

Georgie: Leonard, you know how I got the money to open up my first store? I busted my ass for it, 'cause all the extra money that we had had to go to Sheldon so he could go to college and he could go study in Germany. And do you know what he's never said to me?
Leonard: Danke schon? It's, uh, "thank you" in German.
Georgie: Do you need me to sit on your head?
Leonard: Nope.