Penny: Hey! I got all the beads to the other side.
Howard: It's not a puzzle, Penny.
Amy: Do you really want to be touching that? Do you know how many sick kids? You know, never mind. Knock yourself out.

Amy: Okay, what is going on?
Penny: We just want you to be prepared for any surprises that could happen tomorrow.
Amy: What surprises?
Bernadette: We don't want to spoil anything, but you should know that Sheldon said he's ready to be physical.
Amy: You shut your damn mouth! You actually heard him say this?
Penny: Yes, he said he wants to do something to show you how much you mean to him.
Amy: I can't believe it. I don't know what to say.
Bernadette: Well, we're really happy for you and we know how much-
Amy: I do know what to say. Let's get me waxed!

Sheldon: Sheldon Cooper does not get lucky.
Amy: You and me both, brother.

Amy: Do you have any idea how hard it is to laugh at a knock knock joke that starts "Knock Knock Knock, Amy. Knock Knock Knock, Amy. Knock Knock Knock, Amy"?

Georgie: After all my sacrifices, guess which kid my mom is the most proud of?
Leonard: If it makes you feel any better, my mom's most proud of Sheldon, too.

Georgie: You went away to college after Dad died. Who do you think took care of everything?
Sheldon: Mom did. Mom always took care of everything.
Georgie: Mom was a mess, Missy was a dumb teenager. I had to look after both of 'em.
Sheldon: I talked to Mom all the time. If she was upset, she would have told me.
Georgie: She was protecting you, you idiot, just like everyone always does.
Sheldon: If things were bad, then why didn't you tell me?
Georgie: Because I was protecting you, too. (sighs) You're my baby brother, Sheldon. I know life has been hard for you, but that don't mean it's been easy for the rest of us.

Georgie: Leonard, you know how I got the money to open up my first store? I busted my ass for it, 'cause all the extra money that we had had to go to Sheldon so he could go to college and he could go study in Germany. And do you know what he's never said to me?
Leonard: Danke schon? It's, uh, "thank you" in German.
Georgie: Do you need me to sit on your head?
Leonard: Nope.