Howard: I've known you a long time. You believe in romance more than any person I've ever met and it's hard to see you give up on that. But if you really think marrying this woman is gonna make you happy, then you have my complete and total support.
I will be with you every step of the way.
Raj: Thanks, Howard. That means a lot.
Howard: So, hey, is this wedding gonna be in India?
Raj: Ah, maybe.
Howard: Urgh.

Howard: You know, I'm really glad you decided to learn Mandarin.
Sheldon: Why?
Howard: Once you're fluent, you'll have a billion more people to annoy instead of me.

Josh: So, I have to ask, was the robot sexy?
Howard: It was actually just a mechanical hand.
Josh: 'Cause that's all you need, right?
Howard: You are my brother.

Sheldon: Sheldon Cooper does not cry.
Howard: That's true, you'd rust.

Amy: Hey. Wait a minute, what about us? I mean, we're married now. Maybe we want to buy the house next door.
Sheldon: Well, Amy, we can't move. I'd have to change all the tags in my underwear.
Amy: You can buy new ones.
Sheldon: New house, new underwear. What am I, in the Witness Protection Program?

Sheldon: You're awfully quiet.
Leonard: Sorry.
Sheldon: No, I like it.
Leonard: Got a lot on my mind.
Sheldon: Would you like to talk about it?
Leonard: Not really.
Sheldon: Grape Nuts for breakfast, quiet car ride, things are really breaking my way today.

Amy: What the hell, Penny?!
Penny: I'm gonna need more than that.
Amy: You're not having kids? How could you do this to me?
Penny: How is it any of your business?
Amy: Because your kids were supposed to be friends with my kids. Who's gonna be friends with them now?
Penny: They will find other friends.
Amy: Oh, sure, 'cause Sheldon's DNA plus my DNA equals a kid who knows how to make friends. Grow up!