Amy: Well, granted Penny your secondary sexual characteristics are reasonably bodacious but Priya is highly educated, she's an accomplished professional and she comes from the culture that literally wrote the book on neat ways to have sex. Whereas you, on the other hand, are a community college drop-out who comes from the culture that wrote the book on tipping cows.

Amy: Okay, what is going on?
Penny: We just want you to be prepared for any surprises that could happen tomorrow.
Amy: What surprises?
Bernadette: We don't want to spoil anything, but you should know that Sheldon said he's ready to be physical.
Amy: You shut your damn mouth! You actually heard him say this?
Penny: Yes, he said he wants to do something to show you how much you mean to him.
Amy: I can't believe it. I don't know what to say.
Bernadette: Well, we're really happy for you and we know how much-
Amy: I do know what to say. Let's get me waxed!

Sheldon: Sheldon Cooper does not get lucky.
Amy: You and me both, brother.

Amy: Do you have any idea how hard it is to laugh at a knock knock joke that starts "Knock Knock Knock, Amy. Knock Knock Knock, Amy. Knock Knock Knock, Amy"?

Mrs. Wolowitz: Who's there? Are you a sex criminal?
Howard: Sex criminals don't have key, ma!
Mrs. Wolowitz: Where were you so late?
Howard: I was out with Bernadette
Mrs. Wolowitz: I know what that means, I watch Dr. Phil. I hope to God you used a condom.
Howard: I am not having this conversation with you, ma.
Mrs. Wolowitz: God forbid you get one of them fancy sex diseases.
Howard: Nobody has a disease!
Mrs. Wolowitz:I hope not. I share a toilet with you. Is that what you want, to give your mother herpes?

Amy: So, you feeling better?
Penny: Not really.
Amy: Sheldon, you have a guest who's upset.
Sheldon: I'll make tea.
Penny: Sweetie, it's OK. I don't want tea.
Sheldon: It's not optional.

Sheldon: Priya, if you're experiencing any tension or awkwardness, it may stem from the fact that Leonard and Penny used to, if I might quote Howard, "Do the dance with no pants".