Wil Wheaton: You come face to face with a massive monster with a gaping maw full of teeth, three huge legs, and flailing tentacles. What do you do?
William Shatner: Fellas, it looks like we're facing a, an otyugh. Here's the plan-
Kareem Abdul-Jabbar: Hold on there, Bill.
William Shatner: Now what, Kareem?
Kareem Abdul-Jabbar: How do we know it's not a Neo-otyugh?
William Shatner: Same way I know the difference between an owlbear and a bugbear. Does that answer your question?
Kareem Abdul-Jabbar: No.
Joe Manganiello: Look, there's one way to settle this: we chop it up and look at the pieces.
Kevin Smith: Oh, come on, why do you always got to attack everything? Why can't we just try talking to it?
Joe Manganiello: Big surprise, Podcast here wants to talk.
Kareem Abdul-Jabbar: What do you think, Leonard?
Leonard: I think this is the greatest day of my entire life.
William Shatner: It's all right, buddy, one day you'll meet a girl.

Leonard: What would you be if you were attached to another object by an inclined plane, wrapped helically around an axis?
Sheldon: Screwed?
Leonard: There you go.

Leonard: Penny, as a scientist, my job is to figure out why things happen. But I don't think I'll ever understand how someone like me could get to be with someone like you. You know maybe I don't need to understand it, I just need to be grateful. I love you, Penny.

Sheldon: This song is never going to stop. Have you ever dealt with something so relentlessly irritating?
Leonard: That's a trick question, right?

Wil Wheaton: All right, Professor Proton fans, get ready to meet Dr. Sheldon Cooper and Dr. Amy Farrah Fowler, a pair of real-life scientists who may win the Nobel Prize. That's like the Kids' Choice Award, but with more science and less slime.

Sheldon: Kids' Choice Award? Why would they let kids choose anything? They're basically human larvae.
Wil Wheaton: Well, they are kind of our target audience.
Sheldon: Greetings, children. Toys, am I right?
Amy: He is. He has hundreds of them.

Amy: Okay, imagine you're looking in a mirror. The image you see looks just like you. That's called symmetrical.
Sheldon: Now imagine you have a billion mirrors, and each of them reflects one thing about you correctly and a billion things about you incorrectly. And imagine the set of incorrect things are floating in an abstract n-dimensional hyperspace. Now imagine there was never a mirror to begin with.