Penny: Let's celebrate. What do you want to do?
Leonard: Oh, please don't make me decide another thing.
Penny: Hey, you want to go to SoulCycle with me?
Leonard: Give me a minute, I'll think of something.

Leonard: Penny, as a scientist, my job is to figure out why things happen. But I don't think I'll ever understand how someone like me could get to be with someone like you. You know maybe I don't need to understand it, I just need to be grateful. I love you, Penny.

Leonard: What would you be if you were attached to another object by an inclined plane, wrapped helically around an axis?
Sheldon: Screwed?
Leonard: There you go.

Leonard: My point is, while you're spending all this time on your own, building computers or practicing your cello, what you're really doing is becoming interesting. When people finally do notice you, they're gonna find someone a lot cooler than they thought. And for those of you that were popular in high school, it's over, sorry. Thank you. Congratulations.

Amy: Wow. Déjà vu.
Sheldon: Amy, you're a neuroscientist. you know the latest research into déjà vu suggests it's nothing but the frontal regions of the brain attempting to correct an inaccurate memory.
Amy: You telling me stuff I already know is definitely déjà vu.

Sheldon: How can I tell if I'm doing something for a noble reason or a selfish reason?
Amy: Try saying the thing in your head and see if you can add the words, "That'll show 'em."

Sheldon: Leonard's about to demand a job that I don't think the university will give him. I'm worried he's making a giant mistake. But maybe I only think that because deep down I don't want him to succeed.
Amy: The fact that you're worried about your motivation supports the idea that you genuinely care for your friend.
Sheldon: I do. Thank you, Amy. You know what? After I've talked to Leonard, you've earned yourself a bonus lecture on Sponge Hulk.
Amy: That'll show me.