Leonard: Maybe I am her gay friend.

Leonard: What would you be if you were attached to another object by an inclined plane, wrapped helically around an axis?
Sheldon: Screwed?
Leonard: There you go.

Leonard: Penny, as a scientist, my job is to figure out why things happen. But I don't think I'll ever understand how someone like me could get to be with someone like you. You know maybe I don't need to understand it, I just need to be grateful. I love you, Penny.

Sheldon: This song is never going to stop. Have you ever dealt with something so relentlessly irritating?
Leonard: That's a trick question, right?

Howard: You know, I'm really glad you decided to learn Mandarin.
Sheldon: Why?
Howard: Once you're fluent, you'll have a billion more people to annoy instead of me.

Howard: So you're saying, if in the depths of despair she throws herself at you and demands you take her right there, right now, you'll just walk away?
Leonard: I said I'm her friend, not her gay friend.

Leonard: Before you say anything, have you heard of Schrodinger's cat?
Penny: Actually, I've heard far too much about Schrodinger's cat.
Leonard: Good.
*Leonard and Penny kiss*
Penny: All right, the cat's alive. Let's go to dinner.