Bernadette: Does your mother call you every day at work to see if you had a healthy lunch?
Howard: My mother calls me every day at work to see if I had a healthy bowel movement.

Howard: You know, I'm really glad you decided to learn Mandarin.
Sheldon: Why?
Howard: Once you're fluent, you'll have a billion more people to annoy instead of me.

Howard: So you can never take it (the sweater) off?
Leonard: No.
Raj: Not even to sleep?
Leonard: No.
Howard: So you're just an idiot?
Leonard: It's called proving a point.
Howard: Is the point you're an idiot?

Bernadette: Maybe we should get one of those machines to help her up the stairs.
Howard: You mean a fork lift?

Wil Wheaton: Game over, Moonpie.

Wil Wheaton: Did that guy just say "Revenge is a dish best served cold" to me in Klingon?

Wolowitz: Puppies, how do you stand on puppies?
Bernadette: A puppy once bit my face!
Wolowitz: Of course it did.