Dr. Koothrappali: We heard there was a tornado in Kansas City, is that close to you?
Priya: No.

Penny: So, Dr. Koothrappali, long flight?
Dr. Koothrappali: Twenty hours.
Penny: Ooh, that's rough.
Dr. Koothrappali: Not at all. Did you know that when you fly Transcontinental without your wife, you don't pray for the plane to crash?

Dr. Koothrappali: Relax? Easy for you to say. Your mother isn't cleaning out your bank account. Forty years, the woman never cleaned a thing.

Bernadette: But I thought I'd be more excited.
Dr. Koothrappali: Oh, being excited isn't a guarantee of anything. Rajesh's mother was thrilled when she was pregnant with him. After he was born, she doted on his every move. And you know what happened? He broke her heart, moved halfway around the world, and dates only poor white women. So you never know.

Penny: What do you mean new roommate? What happened to Leonard?
Sheldon: The same thing that happened to Homo Erectus. He was replaced by a superior species.
Raj: I'm the new homo in town.

Penny: So that means, you're a doctor, you're a doctor, you're a doctor, you're a doctor and, Howard, you know a lot of doctors.

Howard: You gotta like this: the girlfriend, the ex-girlfriend, bonding over your rooty-tooty stinky booty? (All but Leonard laugh)
Leonard: Kill me.
Sheldon: It wouldn't help. The human body is capable of being flatulent for hours after death.