Mrs. Wolowitz Howard, are you having a playdate?
Howard: I don't have playdates. I have colleagues.
Mrs. Wolowitz Do their parents know they're here?
Howard: No, but if you keep screaming, maybe they'll hear you.

Mrs. Wolowitz: Howard, help, my hand's stuck in the garbage disposal.
Howard: Let go of whatever piece of food you're holding.
Mrs. Wolowitz: Are you kidding? It's a perfectly good chicken leg.

Mrs. Wolowitz Should I ask Leonard to bring over your homework?
Howard: I don't have homework. I'm a grown man with a master's degree in engineering.
Mrs. Wolowitz Excuse me, Mr. Fancy Pants. Want me to get you a popsicle?

Mrs. Wolowitz I'm not going near that fakakta thing. I'll catch a computer virus.
Howard: You can't catch a computer virus.
Mrs. Wolowitz Oh, so now you're an astronaut and a doctor?

Sheldon: This is the temperature you agreed to in the roommate agreement.
Leonard: Aw, screw the roommate agreement!
Sheldon: No, you don't screw the roommate agreement. The roommate agreement screws you.

Leonard: You know what, go to Hell and set their thermostat.
Sheldon: I don't have to go to Hell. At 73 degrees, I'm there already!

Sheldon: I assure you, you'll be sorry that you wasted your money on an iPod when Microsoft comes out with theirs.
Rajesh: Do you have an opinion about everything?
Sheldon: Yes.
Howard: And you just assume you're right?
Sheldon: It's not an assumption.