Penny: Well we're in Vegas. I want to go downstairs, get a bucket of margaritas, dance until I vomit all over a roulette wheel and watch it go everywhere.
Amy: What if we don't want to vomit?
Penny: Oh, you will. That's why they give you the bucket.

Penny: At one point, they had me figure out how to get a banana out of a puzzle box.
Leonard: Wait, Sheldon gave me a banana in a box. He was testing me, too.
Penny: Unbelievable.
Leonard: And how could a chimp even solve that? That was impossible.
Penny: Really? You couldn't get it out?

Leonard: If I take it off, Sheldon wins.
Penny: Sweetie, every night you don't kill him in his sleep, he wins.

Sheldon: Woman, you are playing with forces beyond your ken.
Penny: Yeah, well your Ken can kiss my Barbie.

Amy: But enough about Penny, let's talk about us. We're looking good.
Bernadette: We are.
Amy: Better than good. I mean look at you, your body's bangin'.
Bernadette: Amy!
Amy: Don't Amy me. We're always talking about how hot Penny is. Come on, scientist to scientist, how big are those hadron colliders?

Sheldon: I know the real reason you never made progress with that idea. You thought of it September 22nd, 2007. Two days later, Penny moved in and so much blood rushed to your genitals, your brain became a ghost town.

Bernadette: Guess who won a hundred dollars playing craps?
Penny: That's a dollar.
Bernadette: Guess who wildly over-tipped a cocktail waitress?