Howard: Don't feel bad. Some day someone will be throwing out your work, too.
Leonard: That someone was Sheldon and the day was yesterday.

Leonard: What would you be if you were attached to another object by an inclined plane, wrapped helically around an axis?
Sheldon: Screwed?
Leonard: There you go.

Sheldon: This song is never going to stop. Have you ever dealt with something so relentlessly irritating?
Leonard: That's a trick question, right?

Leonard: Penny, as a scientist, my job is to figure out why things happen. But I don't think I'll ever understand how someone like me could get to be with someone like you. You know maybe I don't need to understand it, I just need to be grateful. I love you, Penny.

Sheldon: I'd like to take a moment to personally thank Dr. Amy Farrah Fowler, who you may or may not know is the first woman to co-host a flag or banner related Internet infotainment show.
Amy: Take that glass ceiling!

Leonard: You know what, this bottle was meant to celebrate an achievement. Let's make a pact. When one of us gets their first big breakthrough, we'll celebrate by opening this bottle and toasting Professor Abbott.
Howard: I love that.
Raj: Me too.
Leonard: Then, of course, rubbing our success in Sheldon's face.
Howard: Well that's the best part.

Amy: Sheldon, that was beautiful.
Sheldon: If you didn't press record-
Amy: I pressed it!