Penny: What's wrong with cute?
Leonard: It just makes things seem small. It diminishes them.
Penny: So you want me to stop calling your little tushie cute?
Leonard: You can try, but nobody's gonna believe you.

Leonard: What would you be if you were attached to another object by an inclined plane, wrapped helically around an axis?
Sheldon: Screwed?
Leonard: There you go.

Leonard: Penny, as a scientist, my job is to figure out why things happen. But I don't think I'll ever understand how someone like me could get to be with someone like you. You know maybe I don't need to understand it, I just need to be grateful. I love you, Penny.

Sheldon: This song is never going to stop. Have you ever dealt with something so relentlessly irritating?
Leonard: That's a trick question, right?

Sheldon: Well, that stinks. No wonder you got cancelled. Bye.

Amy: Missed one. Now your wish can't come true.
Sheldon: Lucky for you because I wished you were dead.

Sheldon: You don't know what it's like to feel completely frustrated. To have a desire build up within you and be denied any opportunity for release.
Amy: Yeah, sounds like a drag.