Sheldon: Penny, if you wouldn't mind, I'd like to have a conversation about girls.
Penny: I had a weird feeling we'd have a talk like this sooner or later. Are you finally fuzz in weird places?
Sheldon: Penny, please. I'm on the horns of a relationship dilemma. And for the record, I had a full pubis of hair by the time I was 19.
Penny: And for the record, bleugh.

Sheldon: Woman, you are playing with forces beyond your ken.
Penny: Yeah, well your Ken can kiss my Barbie.

Leonard: What am I supposed to do?
Penny: Err, keep your mouth off other women.

Leonard: If I take it off, Sheldon wins.
Penny: Sweetie, every night you don't kill him in his sleep, he wins.

Mrs. Wolowitz: Howard, help, my hand's stuck in the garbage disposal.
Howard: Let go of whatever piece of food you're holding.
Mrs. Wolowitz: Are you kidding? It's a perfectly good chicken leg.

Amy: And action.
Wil Wheaton: And cut! You realize I'm doing this for free, right?
Amy: Yes, and so far we're still not getting our money's worth.

Wil Wheaton: Problem, first time director?