Leonard: I suppose there are worse ways to spend a Friday night. None come to mind.

Leonard: What would you be if you were attached to another object by an inclined plane, wrapped helically around an axis?
Sheldon: Screwed?
Leonard: There you go.

Leonard: Penny, as a scientist, my job is to figure out why things happen. But I don't think I'll ever understand how someone like me could get to be with someone like you. You know maybe I don't need to understand it, I just need to be grateful. I love you, Penny.

Sheldon: This song is never going to stop. Have you ever dealt with something so relentlessly irritating?
Leonard: That's a trick question, right?

Sheldon: You know, in difficult moments like this, I often turn to a force greater than myself.
Amy: Religion?
Sheldon: Star Trek.

Penny: Are you saying that Amy is, oh, what's the scientific word-
Sheldon: Forget science: she's horny.

Amy: Ears and genitalia.
Sheldon: Interesting. Not body parts that usually team up. What about environmental factors. Describe the scene for me?
Amy: I was sitting in a restaurant with Penny and Bernadette drinking water. Carbonated as it was a special occasion. Penny's friend Zack stopped by and said 'hello' and I said 'whoo'.
Sheldon: Who?
Amy: Zack.
Sheldon: Then why did you ask?
Amy: Ask what?
Sheldon: Who?
Amy: Zack.
Sheldon: All right, lets start over. What did you say when Zack walked in?
Amy: 'Whoo'.
Sheldon: Zack.
Amy: Why do you keep saying Zack?
Sheldon: Because you keep saying who?
Amy: I'm not saying 'whoo' now, I said 'whoo' last night.
Sheldon: And the answer is Zack, correct?
Amy: There was no question, I simply said 'whoo'.
Sheldon: All right I think I have enough to go on.