Leonard: Look, I am in the Halo battle of my life here. There's this kid in Copenhagen. He has no immune system so all he does is sit in his bubble and play Halo 24/7.
Howard: Can't you play him some other time?
Leonard: Not if you believe his doctors.

Leonard: What would you be if you were attached to another object by an inclined plane, wrapped helically around an axis?
Sheldon: Screwed?
Leonard: There you go.

Leonard: Penny, as a scientist, my job is to figure out why things happen. But I don't think I'll ever understand how someone like me could get to be with someone like you. You know maybe I don't need to understand it, I just need to be grateful. I love you, Penny.

Sheldon: This song is never going to stop. Have you ever dealt with something so relentlessly irritating?
Leonard: That's a trick question, right?

Howard: Try telling him it's a non-optional social convention.
Penny: What?
Howard: Just do it!
Penny: It's a non-optional social convention.
Sheldon: Oh, fair enough.
Howard: He came with a manual.

Sheldon: What computer do you have? And please don't say a white one.

Store Clerk: Excuse me, Sir, you don't work here.
Sheldon: Yes, well apparently neither does anyone else.