Penny: I think it's great you guys want to get more exercise, but do you really think sports is the right choice for you?
Leonard: What are you saying? We're not coordinated enough to play sports?
Penny: Okay, Leonard, sweetheart, you twisted your ankle playing Scrabble.
Leonard: I got a triple-word score with a double letter Q. If that's not a time to bust out the Scrabble dance, what's the point of having one?

Leonard: What would you be if you were attached to another object by an inclined plane, wrapped helically around an axis?
Sheldon: Screwed?
Leonard: There you go.

Leonard: Penny, as a scientist, my job is to figure out why things happen. But I don't think I'll ever understand how someone like me could get to be with someone like you. You know maybe I don't need to understand it, I just need to be grateful. I love you, Penny.

Sheldon: This song is never going to stop. Have you ever dealt with something so relentlessly irritating?
Leonard: That's a trick question, right?

Howard: My name is Inigo Montoya. You killed my father. Prepare to die.

Raj: My name is Little Orphan Annie. You killed my father. Prepare to die.
Howard: My name is Darth Vader. I am your father. Prepare to die.

Bernadette: Stuart took that rejection like a pro.
Penny: Well, he knew he was on the breast cam.
Amy: I don't have much practice turning men down. It wasn't so much fun.
Bernadette: Oh, you get used to it. Some guys you have to turn down over and over.
Penny: And sometimes we marry them anyway.