Penny: Aw. When he says things like that, I just want to hug him and make everything better.
Leonard: My brother was mean to me, too. Yeah, you probably had it coming.

Leonard: What would you be if you were attached to another object by an inclined plane, wrapped helically around an axis?
Sheldon: Screwed?
Leonard: There you go.

Leonard: Penny, as a scientist, my job is to figure out why things happen. But I don't think I'll ever understand how someone like me could get to be with someone like you. You know maybe I don't need to understand it, I just need to be grateful. I love you, Penny.

Sheldon: This song is never going to stop. Have you ever dealt with something so relentlessly irritating?
Leonard: That's a trick question, right?

Wil Wheaton: Hey, Sheldon. This is Adam Nimoy.
Adam Nimoy: Nice to meet you.
Sheldon: Oh, it's nice to meet you. I admire your father's work very much.
It's not every day I get to meet someone whose life's journey began in my hero's scrotum.

Howard: May I say something?
Bernadette: Is it about how I can't have new wallpaper 'cause your dad left when you were little and your mom died?
Howard: Never mind.

Sheldon: As a child, when faced with a dilemma, my mother encouraged me to ask, "€œWhat would Jesus do?" The answer to that was always, "Love thy neighbor." But my neighbor had a dead tooth, so that wasn't going to happen.
But that's why I changed it to, "€œWhat would Spock do?"
Adam Nimoy: Did you find that helpful?
Sheldon: Yes. Oh, for example, three years ago when I discovered Penny was eating all my Pop-Tarts, instead of getting angry or vindictive, you know, I got a floor safe.
Penny: I knew I could smell 'em.