Leonard: The difference is she's bringing life into the world, and you suck it out.

Leonard: What would you be if you were attached to another object by an inclined plane, wrapped helically around an axis?
Sheldon: Screwed?
Leonard: There you go.

Sheldon: This song is never going to stop. Have you ever dealt with something so relentlessly irritating?
Leonard: That's a trick question, right?

Leonard: My point is, while you're spending all this time on your own, building computers or practicing your cello, what you're really doing is becoming interesting. When people finally do notice you, they're gonna find someone a lot cooler than they thought. And for those of you that were popular in high school, it's over, sorry. Thank you. Congratulations.

Leonard: Hey, did you ever think about the military applications for the guidance system?
Sheldon: Of course.
Leonard: Does it bother you?
Sheldon: No, it did at first. But then I talked it through with Frank and Alicia, and they really helped put things into perspective.
Leonard: Who are these people?
Sheldon: Leonard, friends are like toilet paper. It's good to have extras under the sink.

Raj: Yeah, okay, just do me a favor and stop talking about how great Claire is.
Zack: Anything for you, my little foreign friend.

Raj: Hey, dude, you're killing me with Claire.
Zack: What are you talking about?
Raj: I mean, come on, look at you. You're classically handsome, you've got a swimmer's body. Next to you, I look like me.