Penny: Hi. How did the intervention go?
Sheldon: Unfortunately, we weren't able to convince him to go to rehab.
Penny: Well, based on what you told me, I'm not surprised.

Sheldon: Woman, you are playing with forces beyond your ken.
Penny: Yeah, well your Ken can kiss my Barbie.

Raj: [to Amy] If you were having Sheldon's baby, would you really want him in the room?
Penny: Yeah, if he's in the room when they're making the baby, I'll give you $10.

Penny: I mean, who even reads Scientific American?
Leonard: It's kind of a big deal.
Penny: If it's such a big deal, how come the biggest celebrity they could get for the cover is a molecule?

Sheldon: I am uncomfortable having been included in your lie to Penny.
Leonard: What was I supposed to say?
Sheldon: You could have told her the truth.
Leonard: I could not have said that, it would have hurt her feelings.
Sheldon: Is that a relevant factor?
Leonard: Yes.
Sheldon: Then I suppose you could have agreed to go.
Leonard: What would I have said afterwards?
Sheldon: I would suggest something along the lines of "singing is neither an appropriate vocation nor avocation for you and if you disagree, I recommend you do a CAT scan to locate the tumor which is pressing on the cognitive processing center of your brain".

Sheldon: Leonard?
Leonard: Yes?
Sheldon: (Sarcastic) When we played chess earlier, you were terrific, and I can't wait to play you again. Goodnight!

Toby: Damn you, Chaplain Horrigan.
Penny: I'm sorry?
Toby: The Phillipines: 1992: The Subic Bay Naval Station: A young boy on the cusp of manhood. His only companions, mongrel dogs and malarial mosquitoes. Desperate and alone, he reached out to a man who promised to introduce him to a merciful, loving God. But instead introduced him to a gin-pickled tongue shoved down his adolescent throat. What choice did he have but to drink, shoot, and snort his pain away?
Sheldon: Don't forget genetic predisposition towards addiction.
Toby: That's never been proven.
Sheldon: There have been studies.
Toby: Not double-blind studies!
Sheldon: How could there be double-blind study? Who would be the control group?